Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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3,001 – 3,015 of 3,759 results

3,001

Apexbio Technology LLC Nutlin-3a chiral 675576-98-4 200mg

Nutlin-3a chiral (CAS 675576-98-4) is a small-molecule antagonist targeting mouse double minute 2 (MDM2) which functions as a negative regulator of the tumor suppressor TP53 By binding directly to the TP53-interacting pocket of MDM2 Nutlin-3a blocks the degradation of TP53 stabilizing the protein and activating TP53-dependent pathways Studies in solid tumors and lymphomas indicate that Nutlin-3a induces cell cycle arrest growth inhibition and apoptosis Research has demonstrated antitumor activity in vitro and in vivo highlighting its utility in studying TP53-related cell signaling pathways and its potential in cancer research applications

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3,002

Medchemexpress LLC Bromopride | 4093-35-0 | 99.5% | 200 MG

Bromopride | 4093-35-0 | 99.5% | 200 MG

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3,003

Medchemexpress LLC Corticosterone | 50-22-6 | 99.8% | 200 MG

Corticosterone is an orally active glucocorticoid produced by the adrenal cortex. It is involved in regulating neuronal functions within the limbic system, including the hippocampus, prefrontal cortex, and amygdala.

Enhances Rab-mediated AMPAR membrane traffic through SGK-induced phosphorylation of GDI.
Has an immunosuppressive effect by interfering with dendritic cell maturation.

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3,004

Medchemexpress LLC Afalanine (N-Acetyl-DL-phenylalanine) | 2901-75-9 | 99.9% | 200 MG

Afalanine (N-Acetyl-DL-phenylalanine) is an endogenous metabolite of an endophytic fungus with antidepressant activity. It can be used in combination with antibiotics to prevent renal damage.

Endogenous metabolite of an endophytic fungus
Antidepressant activity
Can be used in combination with antibiotics to prevent renal damage
For research use only

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3,005

Medchemexpress LLC Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG

Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG

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3,006

Medchemexpress LLC Guanidinoethyl sulfo 25mg | 25MG

Guanidinoethyl sulfo 25mg | 25MG

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3,007

TARGETMOL CHEMICALS INC TPEN 200MG

Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. Purity 99.79%

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3,008

Medchemexpress LLC Anthra[1,9-cd]pyrazol-6(2H)-one | 129-56-6 | 99.7% | 200 MG

SP600125 is a reversible, ATP-competitive inhibitor of c-Jun N-terminal kinases (JNK1, JNK2, JNK3) used as a research reagent. Reported IC50 values are 40 nM for JNK1, 40 nM for JNK2, and 90 nM for JNK3. The compound has also been reported to inhibit ferroptosis and to induce conversion from autophagy to apoptosis in certain cancer cells.

ATP-competitive inhibitor of JNK1, JNK2, and JNK3.
IC50 values: 40 nM (JNK1), 40 nM (JNK2), 90 nM (JNK3).
High purity (99.73%).
Available as a 200 MG pack for research and analytical use.
Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (2 years) or -20°C (1 year).
Intended for research use only.

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3,009

Medchemexpress LLC Sulfo Cy7 tyramide | 99.1% | 802.01 | C43H51N3O8S2 | 10 MG

Sulfo Cy7 tyramide is a near-infrared fluorescent tyramide reagent (Ex = 740 nm, Em = 770 nm) used as the reporter substrate for horseradish peroxidase (HRP)-catalyzed deposition in tyramide signal amplification (TSA). It is supplied as a solid with demonstrated high purity and is intended for fluorescence-based detection, including multiplex immunohistochemistry.

Near-infrared excitation/emission: 740/770 nm.
High purity (LCMS: 99.13%).
Compatible with HRP-based tyramide signal amplification and multiplex IHC.
Soluble in DMSO at 12.5 mg/mL (requires ultrasonic).
Store protected from light at 4°C; in solvent: -80°C (6 months) or -20°C (1 month).

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3,010

TARGETMOL CHEMICALS INC Azilsartan 200MG

Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker that acts as an Angiotensin 2 Type 1 Receptor Antagonist, leading to a physiologic effect of decreased blood pressure. Purity 99.87%

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3,011

TARGETMOL CHEMICALS INC SPP-86 10MG

Also available in 1 mL, 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM. Purity 98.19%

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3,012

TARGETMOL CHEMICALS INC Cephalothin 200MG

Also available in 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Cephalothin is a beta-lactam antibiotic, inhibits class C beta-lactamase AmpC (Ki 0.32 uM). Purity 99.62%

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3,013

Medchemexpress LLC Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt | 185332-92-7 | MFCD17215919 | 98.8% | 382.28 g/mol | C12H11N2NaO9S | 1 ML

Sulfo-GMBS is a water-soluble, heterobifunctional cross-linker that links primary amines to sulfhydryl groups via a non-cleavable maleimide spacer. Supplied as a ready-to-use 10 mM solution in DMSO or as a solid, it is intended for protein and peptide conjugation, immobilization, and labeling in biochemical and assay workflows.

Water-soluble amine-thiol cross-linker suitable for protein and peptide conjugation.
Provides a short, non-cleavable spacer facilitating stable linkage between functional groups.
Available as a 10 mM solution in DMSO or in solid form for flexible use.
High purity (approximately 98.8%) supports reproducible conjugation reactions.
Soluble in DMSO at 50 mg/mL (≈130.8 mM) for easy preparation of working solutions.
Recommended storage: solid at -20°C sealed; in solvent at -80°C for extended stability.

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3,014

Apexbio Technology LLC SKF38393 HCl 62717-42-4 200mg

SKF38393 HCl is a selective dopamine D1 receptor agonist exhibiting activity through direct binding and stimulation of D1 receptors Activation of D1 receptors primarily induces adenylyl cyclase stimulation and increases cAMP-dependent protein kinase signaling subsequently modulating neuronal differentiation growth and dopamine-mediated functional responses Experimental evidence indicates that SKF38393 administration impacts gene expression patterns related to dopamine receptor-sensitive neuronal pathways and neuropeptides Additionally in vitro studies report SKF38393 to inhibit proliferation of certain tumor cell lines exemplified by decreased cell growth in breast carcinoma-derived MCF-7 cells at submicromolar concentrations It is widely utilized as a pharmacological tool in neuroscience and oncology research

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3,015

Apexbio Technology LLC CUDC-907 1339928-25-4 200mg

CUDC-907 (CAS 1339928-25-4) is a dual inhibitor targeting histone deacetylases (HDACs 1 2 3 10) and class I phosphatidylinositol 3-kinases (PI3K) It exhibits nanomolar inhibitory activity against these enzymes blocking PI3K-mediated Akt signaling and increasing acetylation of histones and non-histone substrates (e g tubulin p53) In cancer cell models CUDC-907 induces G2-M phase arrest and reduces phosphorylation of downstream proteins such as p70S6 4EBP-1 MEK STAT3 and SRC Preclinical studies demonstrate its anti-tumor activity in lymphoma and NSCLC xenografts making it relevant for oncology research

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Quinolines and derivatives

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Apexbio Technology LLC Nutlin-3a chiral 675576-98-4 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Bromopride | 4093-35-0 | 99.5% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Corticosterone | 50-22-6 | 99.8% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Afalanine (N-Acetyl-DL-phenylalanine) | 2901-75-9 | 99.9% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Guanidinoethyl sulfo 25mg | 25MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC TPEN 200MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Anthra[1,9-cd]pyrazol-6(2H)-one | 129-56-6 | 99.7% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Sulfo Cy7 tyramide | 99.1% | 802.01 | C43H51N3O8S2 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC Azilsartan 200MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC SPP-86 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

TARGETMOL CHEMICALS INC Cephalothin 200MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt | 185332-92-7 | MFCD17215919 | 98.8% | 382.28 g/mol | C12H11N2NaO9S | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC SKF38393 HCl 62717-42-4 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC CUDC-907 1339928-25-4 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More